BIOEDGE
LONGEVITY SUMMIT
Where Biohacking Starts with NO
NO to one-size-fits-all protocols.
NO to optimizing a body you don’t understand.
Are you ready to slow down and decide carefully about your future?
Living Well, Longer, Together
Experience the Summit
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ELIMINATE
Before you add anything, remove what's interfering. Chemical, digital, and behavioral noise all distort signals.
DECODE
Your body speaks in signals, not symptoms. Learn to notice what your systems are communicating.
GAIN
Optimization works after interference is eliminated and signals are decoded. The order matters.
EXECUTE
You're in it for the long term. Be patient and consistent, long enough for the body to respond.
15 Biological Systems
Breath
Respiratory system, oxygen delivery, breathing patterns
Circulation
Heart, blood vessels, blood flow, cardiovascular health
Consciousness
Awareness, presence, thought quality, mental clarity
Defense
Immune function, inflammation, autoimmunity
Detoxification
Liver function, lymphatic drainage, elimination
Digestive
Gut health, microbiome, nutrient absorption
Emotional
Mental wellbeing, mood regulation, psychological health
Energy Production
Mitochondrial function, ATP, metabolic efficiency
Hormonal
Endocrine system, hormone balance, thyroid, adrenals
Hydration
Fluid balance, electrolytes, cellular hydration
Nervous System
Brain-body connection, neural pathways, vagal tone
Regeneration
Cellular repair, stem cells, longevity pathways
Stress Response
Fight or flight, cortisol regulation, stress adaptation
Structure & Movement
Bones, joints, connective tissue, muscles, mobility
Temperature
Heat regulation, cold tolerance, metabolic temperature
Presentations
Nathalie NiddamBioregulators & Peptides: Tap Your Body's Hidden Repair Code
Longevity educator and podcaster Nathalie Niddam explores bioregulators—tiny peptide chains that penetrate directly into cells to activate DNA repair and restore gene expression. Drawing from the groundbreaking work of Professor Khavinson's peptide theory of aging, this session demystifies how these two-to-four amino acid complexes differ from conventional peptides, why they don't need receptors to work, and how they address aging at the cellular motherboard. Niddam shares her favorite six "desert island" bioregulators and explains their role in a comprehensive longevity strategy, while navigating the evolving regulatory landscape and distinguishing between synthetic and animal-derived formulations.
Jason SonnersBreathing at Depth: How Pressure Transforms Your Cellular Recovery
Dr. Jason Sonners reveals how hyperbaric oxygen therapy fundamentally transforms cellular recovery through the physics of pressure. Drawing on 17 years of clinical experience and current PhD research in molecular biology, he demystifies how pressurized oxygen bypasses normal physiological limits to deliver therapeutic benefits unavailable through any other modality. This session breaks down the molecular mechanisms behind HBOT's effects on ATP production, stem cell mobilization, inflammation reduction, and tissue regeneration—explaining why this underutilized therapy deserves a central role in performance optimization and longevity protocols.
Andrew BustamanteCIA Secrets: Optimizing Human Energy for Peak Performance
Former CIA covert officer Andrew Bustamante reveals how intelligence operatives harness bioenergetics—the measurable science of human energy—for peak performance and influence. Drawing from classified tradecraft, Bustamante decodes the physics behind mitochondrial energy generation, body language, and energy projection. This session exposes why government agencies invest heavily in human energy research for strategic advantage and demonstrates how understanding energy density, transfer, and direction can optimize cognitive performance, persuasion, and interpersonal dynamics in high-stakes situations.
Ben AzadiFrom Sugar Burner to Fat Burner: Mastering Metabolic Freedom
Ben Azadi, founder of Keto Kamp and author of the New York Times bestseller Metabolic Freedom, reveals why most biohackers are unknowingly harming their health despite optimizing protocols. Through the concept of hormesis and practical demonstrations, Azadi explains how cold plunges, fasting, and red light therapy can become toxic stressors when your "stress bucket" is full. Drawing from his personal battle with Raynaud's syndrome and mercury poisoning, he shares the six science-backed strategies he used to raise his hormetic ceiling—including high-dose melatonin, mouth taping, and HRV tracking—enabling him to finally thrive with metabolic flexibility.
Mark YoungHacking Heart Health Through Isometric Training
Mark Young, CEO of Zona Health, challenges conventional approaches to cardiovascular health by exposing the limitations of pharmaceutical-first treatments and dietary myths surrounding hypertension. He introduces the science behind isometric exercise as a natural alternative, demonstrating how the Zona Plus device leverages static resistance training to stimulate nitric oxide production and improve blood flow. Young critiques the medical establishment's symptom-masking approach while presenting evidence-based solutions that address root causes of cardiovascular dysfunction through targeted biohacking interventions.
Bernard SiegelThe Future of Longevity: Policy, Innovation, and Patient Advocacy
Bernard Siegel, Executive Director of the Healthspan Action Coalition and veteran regenerative medicine advocate, delivers a critical examination of the regulatory crossroads facing biohacking, stem cell research, and longevity medicine. Drawing on his 22-year journey from courtroom attorney to patient advocate and policy expert, Siegel explores how the current political landscape could either accelerate or extinguish innovation in peptides, psychedelics, stem cells, and emerging therapies. This session confronts the tension between regulatory oversight and scientific freedom at a pivotal moment for the health optimization movement.
Gary BreckaUnlock the Secret to Living a Longer, Fuller Life with Gary Brecka Part 1
Former insurance mortality expert Gary Brecka reveals groundbreaking insights from 22 years of predicting human lifespans to the month. Drawing from exclusive life insurance data on 370 million lives, Brecka exposes how oxygen depletion drives aging and disease through hypoxic curves. He shares the science behind modifiable risk factors that could add seven years to your healthspan, explores the hidden connections between hormone balance and oxygen transport, and explains why most health conditions aren't consequences of aging but correctable deficiencies. A data-driven approach to unlocking longevity secrets.
Gary BreckaUnlock the Secret to Living a Longer, Fuller Life with Gary Brecka Part 2
Human biologist Gary Brecka reveals how five critical genes control methylation pathways that impact everything from gut health to sleep quality and mood regulation. Drawing from his expertise in mortality modeling and functional medicine, Brecka breaks down the MTHFR, MTR, and MTRR gene mutations that affect 44% of the population, explaining how these genetic variations create neurotransmitter deficiencies often misdiagnosed as mood disorders, food allergies, or chronic gut issues. He demonstrates how simple methylated vitamin supplementation can restore proper gene function and resolve conditions like acid reflux, insomnia, and digestive problems.
Sandy MartinWhat is Biohacking?
Join bioEDGE Coach founder Sandy Martin as she moderates an insightful panel exploring the true meaning of biohacking beyond the hype. Featuring Jean Fallacara from Lifespanning and longevity enthusiast Dave Pascoe, this discussion reveals diverse approaches to optimization—from brain-first strategies to supplement cycling. Discover practical insights on starting your biohacking journey, the importance of eliminating toxins before adding supplements, and why happiness might be the ultimate biohack. Perfect for beginners and experienced biohackers seeking evidence-based perspectives on health optimization.
How Electromagnetic Fields Support Your Body's Natural Healing Rhythms
Discover how combining PEMF therapy with sound frequencies can restore cellular resonance, supporting everything from mitochondrial function to nervous system regulation in a practical home-use system.
How Light and Sound Training Can Sharpen Your Brain's Recovery Mode
Your brain cycles through distinct electrical states every day, and how smoothly it transitions between them affects everything from sleep quality to cognitive sharpness. Brainwave entrainment, paired with light therapy, offers a structured way to train that flexibility.
Metabolic Flexibility: Your Body's Natural Ability to Switch Between Fuel Sources
Modern eating patterns have locked most people into glucose-burning mode, but your cells remember how to be metabolically flexible. Strategic ketogenic nutrition and fasting can reactivate your body's natural ability to switch between fuel sources.
Seven Inputs Your Brain Expects Every Day, Ordered by How Fast You'd Die Without Them
Your brain consumes 20% of your oxygen and calories despite being 2% of your body weight. Giving it the right inputs, in the right order, may be the most overlooked strategy in health optimization.
Telomere Length: The Cellular Clock You Can Actually Influence
Scientists have discovered how to rebuild your cells' protective caps—telomeres—that shorten with age. New research shows telomerase activation can reduce inflammation by 62% and measurably reverse cellular aging markers.
The Gut-Brain Axis: Your Body's Hidden Highway to Mental Clarity and Digestive Calm
Recent research reveals how specific wavelengths of red and near-infrared light can enhance the gut-brain axis by boosting mitochondrial ATP production, supporting both mental clarity and digestive comfort through targeted cellular energy optimization.
The NAD+ Optimization Blueprint: Why Testing Beats Guessing for Cellular Energy
Discover why measuring intracellular NAD+ levels transforms guesswork into precision optimization, helping you maintain cellular energy and vitality decades longer.
What Birth Tissues Reveal About Your Body's Built-In Repair System
Your body already contains the machinery for regeneration. Researchers are now exploring how perinatal birth tissues, rich in growth factors, extracellular vesicles, and matrix, may hold clues to restoring the repair capacity that declines with age.
Why Traditional Fermentation Makes Protein More Powerful for Longevity
Ancient fermentation unlocks 30% more protein absorption while creating longevity compounds modern processing destroys. Discover why grass-fed beef transformed through time-honored methods outperforms supplements.
Why Your Biohacking Stack Isn't Working
Most biohackers fail because they optimize before eliminating what's sabotaging their biology. Discover why removing interference beats adding interventions—and how to finally make your health stack work.
Why Your Hormones Hold the Key to Thriving Through Midlife
Discover how adaptogenic herbs and alkaline nutrition can transform your midlife experience. Dr. Anna Cabeca's functional approach helps women navigate hormonal shifts with energy, clarity, and confidence.
Your Body Already Knows How to Repair Itself. Here's How to Give It More Resources.
Stem cell availability declines with age, leaving tissues that once healed quickly struggling to repair. Discover how specific botanicals can increase circulating stem cells by up to 80%, restoring your body's natural renewal capacity.
Choose the Long Game.
Build connection. Decide carefully. Grow old together.
Hertility announced as Women’s Health Partner for Longevity Show
Hertility has been named Scientific Lead Partner for the Women's Health Summit at the 2026 Longevity Show, positioning female biology as a structural framework—not peripheral content—for longevity science. The partnership addresses a fundamental data gap: longevity research has been calibrated to male physiology, requiring sex-specific diagnostic infrastructure and longitudinal data to advance clinical outcomes.
- Female aging follows distinct cellular, endocrine, and immunological pathways requiring sex-specific
- Reproductive aging precedes and predicts broader systemic change, serving as sentinel event for card
- Longevity science requires architectural shift from awareness narratives to diagnostic infrastructur
Longevity Significance
The scientific distortion embedded in longevity research—applying male-derived models to female biology—has obscured critical early-warning signals within hormonal and reproductive systems that predict systemic aging trajectories. Menopause transition markers (cardiometabolic shifts, bone density changes, cognitive resilience patterns) function as measurable inflection points that historically have been excluded from longevity frameworks, creating downstream clinical blind spots. Moving beyond narrative to diagnostic infrastructure means capturing sex-specific biomarkers, endocrine transitions, and immunological shifts that operate on fundamentally different timelines in women—a correction that changes both prevention strategy and clinical outcome prediction across the lifespan.
Klothea initiates longevity-focused human trial of klotho therapy
Klothea Bio has initiated a Phase 1b trial of AKL003, an mRNA therapy designed to elevate circulating alpha klotho protein levels in healthy adults. The trial represents a direct approach to testing whether increased klotho—a protein associated with organ protection and repair across multiple physiological systems—can favorably shift biomarkers linked to human lifespan and biological age.
- mRNA therapy delivers genetic instruction to boost endogenous klotho production via lipid nanopartic
- Trial evaluates safety, tolerability, and klotho elevation in 21 healthy volunteers aged 25–75
- Exploratory endpoints include inflammatory markers, cardiovascular function, mitochondrial activity,
Longevity Significance
Klotho operates as a systemic protectant across cardiovascular, renal, neurological, and skeletal function—domains central to both disease prevention and the extension of healthspan. By using mRNA technology to instruct cells to manufacture klotho rather than delivering the protein externally, the approach circumvents prior technical barriers to consistent dosing and sustained expression. The trial's measurement strategy—combining inflammatory and metabolic markers with epigenetic aging assessments and functional capacity—reflects a shift toward capturing biological age reduction rather than waiting for mortality data, making it possible to detect meaningful changes within a practical timeframe. Success would establish klotho augmentation as a testable intervention that addresses aging as a target rather than waiting for disease-specific endpoints.
Nanoplastics found in the brain raise new aging questions
Nanoplastics have been detected in human brain tissue and show correlation with neurodegenerative disease severity and accelerated aging markers. The particles' ability to cross biological barriers and interact with pathological proteins suggests chronic, low-level exposure represents a longevity risk distinct from acute toxicity.
- Nanoplastics detected in brain tissue, blood, organs, and arterial plaques across all ages
- Higher nanoplastic concentrations found in Alzheimer's and vascular dementia tissues versus healthy
- Particles may scaffold protein misfolding of alpha-synuclein, amyloid-beta, and tau over decades
Longevity Significance
Nanoplastic exposure represents a persistent environmental interference that accumulates across the lifespan and may accelerate the protein aggregation processes underlying neurodegeneration. The detection of these particles in neural tissue even among younger individuals indicates continuous exposure rather than a late-life risk factor. Understanding how to identify and reduce this source of chronic biological burden—and to recognize its contribution to declining brain function—becomes essential for preventing age-related cognitive decline. The gap between laboratory models and actual environmental exposure underscores the need for research that addresses the irregular, weathered particles found in living systems rather than engineered models.